Metabolic Fate of MC903 (2). Absorption, Distribution, Metabolism and Excretion after Single Dermal Application in Rats.

Absorption, distribution, metabolism, and excretion of donepezil (Aricept) after a single oral administration to Rat.

Donepezil hydrochloride (Aricept) is a drug for the treatment of Alzheimer's disease. The absorption, distribution, metabolism, and excretion of donepezil were investigated in male Sprague-Dawley rats after a single oral administration. Orally administered (14)C-labeled donepezil was absorbed rapidly. The plasma level of unchanged donepezil declined more rapidly than that of radioactivity, and ...

Absorption, Distribution, and Excretion of 14C-APX001 after Single-Dose Administration to Rats and Monkeys

Metabolic fate of 5-ethoxycarbonyl-3-morpholinosydnonimine (SIN-10). 1. Absorption, excretion and tissue distribution in rats and mice.

chemical structure. The pharmacological studies on SIN-10 by Takenaka et al. (2) showed a sustained hypotensive effect in rabbits. The similar effect was also confirmed in the dog, cat and rat by Kikuchi et al. (3). In order to provide a biochemical basis for the pharmacological and toxicological mechanisms, the metabolic aspects of SIN-10 have been studied in rats and mice. The present paper d...

Absorption, distribution, metabolism, and excretion of [14C]‐dasotraline in humans

Dasotraline is a dopamine and norepinephrine reuptake inhibitor, and the early clinical trials show a slow absorption and long elimination half-life. To investigate the absorption, distribution, metabolism, and excretion of dasotraline in humans, a single dose of [14C]-dasotraline was administered to eight healthy male adult volunteers. At 35 days, 90.7% of the dosed radioactivity was recovered...

Absorption, distribution, metabolism, and excretion of ticagrelor in healthy subjects.

Ticagrelor [(1S,2S,3R,5S)-3-[7-[[(1R,2S)-2-(3,4-difluorophenyl) cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)-1,2-cyclopentanediol)] is a reversibly binding oral P2Y(12) receptor antagonist in development for the prevention of thrombotic events in patients with acute coronary syndromes. The pharmacokinetics, metabolism, and excretion of ticagrelor...